differential immunogenicity of a recombinant hepatitis b vaccine in iranian neonates: influence of ethnicity and environmental factors

نویسندگان

abdollah jafarzadeh

department of immunology, school of public health, tehran university of medical sciences, tehran jalal khoshnoodi

department of immunology, school of public health, tehran university of medical sciences, tehran shayesteh ghorbani

kerman health center, kerman university of medical sciences, kerman saleh mohaghegh hazrati

department of immunology, school of public health, tehran university of medical sciences, tehran babak faraj mazaheri

چکیده

objective: to compare immunogenicity of a recombinant hepatitis b (hb) vaccine in two groups of neonates born in two cities of iran with different geographic and ethnic backgrounds.   materials and methods: ten micrograms of a recombinant hb vaccine was administered under field condition to iranian healthy neonates at 0, 1.5 and 9 months intervals. the subjects consisted of two groups of 290 and 231 neonates selected from two cities located at north-west (urmia) and south-east (kerman) of iran, respectively. the level of anti-hbs antibody was quantitated in serum 2-4 weeks after administration of the last vaccine dose, by sandwich elisa.   results: a higher seroprotection rate (anti-hbs> 10 iu/l) (98.3% vs. 96.1%) and significantly increased serum anti- hbs antibody titer (11869 vs. 6104 iu/l) (p

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عنوان ژورنال:
iranian journal of immunology

جلد ۱، شماره ۲، صفحات ۹۸-۱۰۴

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